(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanone → HCID 67219076, compound

HRID 916777Notes

Reaction equation

HRID 916777 reaction equation
ClC1C2C=CN(CC3CC3)C=2N=CN=1.[NH2:15][C:16]1[C:17]2[C:24]([C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([NH2:33])[CH:28]=3)=[O:26])=[CH:23][N:22]([CH:34]3[CH2:38][CH2:37][CH2:36]C3)[C:18]=2[N:19]=[CH:20][N:21]=1>>[NH2:15][C:16]1[C:17]2[C:24]([C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([NH2:33])[CH:28]=3)=[O:26])=[CH:23][N:22]([CH2:34][CH:38]3[CH2:36][CH2:37]3)[C:18]=2[N:19]=[CH:20][N:21]=1

Participants

3

Reactant 2

HCID 11859044(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)methanoneHCID 73554645HCID 73554645, compound

Product 1

HCID 67219076HCID 67219076, compound

Procedure

The title compound was prepared from 4-Chloro-7-cyclopropylmethyl-7H-pyrrolo[2,3-d]pyrimidine by procedures analogous to those described for the preparation of (4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-amino-phenyl)-methanone. MS: 308.4 (MH+); HPLC Rf: 4.17 min. (HPLC method 4); HPLC purity: 100%.

Sources & evidence

ORD record
ord-7daba742139242638ec28355817be6f7
Source dataset
uspto-grants-2007_09
Patent number
US07271262B2

Reaction notes

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