反应详情

To 40.81 g losartan of Example 1 in 235 ml i-propanol, a solution of 5.5 g potassium hydroxide in 5.7 ml of water was added at a temperature of 38-40° C. to a pH 12 during half an hour. Approximately 35 ml of azeotropic mixture i-propanol/water were removed by distillation, 141.5 ml of n-heptane were added, and reaction mixture was stirred at room temperature until a white precipitate was formed. The resulting precipitate was diluted with 54 ml n-heptane, filtered, washed with 108 ml n-heptane, and dried in vacuo at 50° C. to yield 21.36 g of losartan potassium.

1. customApproximately 35 ml of azeotropic mixture i-propanol/water were removed by distillation, 141.5 ml of n-heptane
2. additionwere added
3. customreaction mixture
4. customwas formed
5. filtrationfiltered
6. washwashed with 108 ml n-heptane
7. customdried in vacuo at 50° C.