反应详情

To 40.81 g of losartan of Example 1 in 235 ml of i-propanol, 6.07 g magnesium ethoxide were added, and stirred at reflux temperature overnight. Reaction mixture was hot filtered, 650 ml n-heptane were added, and cooled to room temperature for the product to precipitate. It was filtered and washed with 110 ml n-heptane, and dried in vacuo at 50° C. to yield 37.9 g losartan magnesium.

1. temperatureat reflux temperature overnight
2. customReaction mixture
3. additionwere added
4. customto precipitate
5. filtrationIt was filtered
6. washwashed with 110 ml n-heptane
7. customdried in vacuo at 50° C.