反应详情

To 40.81 g losartan of Example 1 in 235 ml i-propanol, 3.92 g calcium hydroxide were added, and it was stirred at reflux temperature for 1 hour, and hot filtered. 410 ml n-heptane were added to the filtrate and cooled to room temperature. The solvent was decanted from a resinous residue, and 820 ml n-heptane were added. It was stirred until a white solid crystallized. It was filtered, washed with 110 ml n-heptane, and dried in vacuo at 50° C. to yield 39.2 g losartan calcium.

1. temperatureat reflux temperature for 1 hour
2. customThe solvent was decanted from a resinous residue, and 820 ml n-heptane
3. additionwere added
4. stirringIt was stirred until a white solid
5. customcrystallized
6. filtrationIt was filtered
7. washwashed with 110 ml n-heptane
8. customdried in vacuo at 50° C.