反应详情

As already described, to 10.2 g crude losartan of Example 14 (chromatographic purity 98.73%) in 59 ml i-propanol, a solution of 1.4 g potassium hydroxide in 1.5 ml water at a temperature of 38-40° C. to a pH of 10 over half an hour was added. Approximately 19 ml of azeotropic mixture i-propanol/water were removed by distillation, 36 ml n-heptane were added, and reaction mixture was stirred at room temperature until a white solid was formed. The resulting mixture was diluted with 14 ml n-heptane, filtered, washed with 26 ml n-heptane, and dried in vacuo at 50° C. to yield 8.57 g losartan potassium (yield: 77%, chromatographic purity: 99.67%).

1. customApproximately 19 ml of azeotropic mixture i-propanol/water were removed by distillation, 36 ml n-heptane
2. additionwere added
3. customreaction mixture
4. customwas formed
5. filtrationfiltered
6. washwashed with 26 ml n-heptane
7. customdried in vacuo at 50° C.