反应详情

To 40.81 g losartan (chromatographic purity 98.73%) in 153 ml i-propanol, a mixture of 10 g potassium hydroxide, 5.1 ml water, and 100 ml i-propanol was added at a temperature of 38-40° C. to a pH of 10-11 during half an hour. Approximately 140 ml of the solvent (i-propanol/water mixture) were removed by distillation, and 92 ml n-heptane were added. It was stirred at room temperature until a white precipitate was formed. The precipitate was diluted with 54 ml n-heptane, filtered, washed with 70 ml n-heptane, and dried in vacuo at 50° C. to yield 38.4 g losartan potassium (yield: 86%, chromatographic purity: 99.67%).

1. additionwas added at a temperature of 38-40° C. to a pH of 10-11 during half an hour
2. customApproximately 140 ml of the solvent (i-propanol/water mixture) were removed by distillation, and 92 ml n-heptane
3. additionwere added
4. customwas formed
5. filtrationfiltered
6. washwashed with 70 ml n-heptane
7. customdried in vacuo at 50° C.