HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9171Generated: October 25, 2026
Ethyl isocyanate → 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea
https://huagongshe.com/reaction/9171
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
Reaction Steps
About 0.75 g of 6-bromo-1,3-benzothiazol-2-amine (crude) is dissolved in about 15 mL DMF. About 0.5 mL of ethylisocyanate is added followed by about 0.9 mL triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07091227B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-0c31608d9ad04d16b80f61e52ee18c38 |
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| Source note | uspto-grants-2006_08 |
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