Trifluoroacetic acid → HCID 43599764, compound

HRID 917347Notes

Reaction equation

HRID 917347 reaction equation
[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20](=[O:26])[CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])#[N:2].FC(F)(F)C(O)=O>ClCCl>[C:1]([C:3]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:7][C:6]=2[S:5][C:4]=1[NH:19][C:20](=[O:26])[CH:21]([CH2:24][CH3:25])[CH2:22][CH3:23])#[N:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58962834HCID 58962834, compound

Product 1

HCID 43599764HCID 43599764, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the intermediate isolated in Step B in 100 mL of dichloromethane was added 25 mL of trifluoroacetic acid. After 2 h at ambient temperature, the reaction was diluted with an equal volume of saturated aqueous NAHCO3. The mixture was extracted twice with dichloromethane, and the combined organic layers were dried (Na2SO4) and concentrated in vacuo, affording the title compound.

Workup

  1. additionthe reaction was diluted with an equal volume of saturated aqueous NAHCO3
  2. extractionThe mixture was extracted twice with dichloromethane
  3. dry with materialthe combined organic layers were dried (Na2SO4)
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2e70f359e44a4a0aa0669b94ed2fd955
Source dataset
uspto-grants-2007_09
Patent number
US07273876B2

Reaction notes

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