反应详情

温度

100 °C

To 100 ml of N,N-dimethylformamide, 4.56 g (20 mmol) of 6,6-difluoro-5-methyl-5-hexenyl methanesulfonate and 4.70 g (26 mmol) of sodium dimethyldithiocarbamate dihydrate were dissolved, followed by stirring at 100° C. for 3 hours. The reaction liquid was poured into water and extracted with ethyl acetate. The organic layer was washed with water and a saturated saline solution in this order, followed by drying over anhydrous magnesium sulfate and concentrating under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:10) to obtain 2.60 g (yield: 51%) of 6,6-difluoro-5-methyl-5-hexenyl N,N-dimethyldithiocarbamate.

1. customThe reaction liquid
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialby drying over anhydrous magnesium sulfate
5. concentrationconcentrating under reduced pressure
6. customThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:10)