反应详情

To a stirred suspension of 500 mg (1.88 mmol) 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine and 0.46 ml (5.63 mmol) pyridine in 15 ml dichloromethane and 5 ml tetrahydrofuran was added 0.28 ml (2.25 mmol) phenyl chloroformate and stirring continued at 50° C. for 3 h. The reaction mixture was then filtered and the filtrate concentrated in vacuo. Flash chromatography (ethyl acetate/heptane) afforded 535 mg 74%) (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester as a white solid. ES-MS m/e (%): 387 (M+H+, 100).

1. filtrationThe reaction mixture was then filtered
2. concentrationthe filtrate concentrated in vacuo