HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → 2-(4-Hydroxy-piperidin-1-ylmethyl)-N-(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(Chloromethyl)pyridine-4-carbonyl chloride | HCID 21919232 | — |
| Reactant | 7-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine | HCID 86038553 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(4-Hydroxy-piperidin-1-ylmethyl)-N-(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-isonicotinamide | HCID 86597270 | — |
Reaction Steps
From 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine with 2-chloromethyl-isonicotinoyl chloride and N-ethyldiisopropylamine in 1,2-dichloroethane and THF; then subsequent treatment with 4-hydroxypiperidine in NMP. ES-MS m/e (%): 485 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07273865B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-911660bfa8be484db32efec264527cbf |
| Source note | uspto-grants-2007_09 |