反应详情

From 7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine with 2-chloromethyl-isonicotinoyl chloride and N-ethyldiisopropylamine in 1,2-dichloroethane and THF; then subsequent treatment with 4-hydroxypiperidine in NMP. ES-MS m/e (%): 485 (M+H+, 100).