Pyridine → HCID 86597272, compound

HRID 917450Notes

Reaction equation

HRID 917450 reaction equation
C1(O[C:8](=[O:27])[NH:9][C:10]2[S:11][C:12]3[C:13]([N:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[N:14][CH:15]=[C:16]([O:19][CH3:20])[C:17]=3[N:18]=2)C=CC=CC=1.[N:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.Cl[CH:35](Cl)[CH3:36]>O1CCCC1>[CH3:20][O:19][C:16]1[C:17]2[N:18]=[C:10]([NH:9][C:8]([N:28]3[CH2:33][CH2:32][C:31]4([C:8](=[O:27])[N:9]([CH3:10])[CH2:35][CH2:36]4)[CH2:30][CH2:29]3)=[O:27])[S:11][C:12]=2[C:13]([N:21]2[CH2:22][CH2:23][O:24][CH2:25][CH2:26]2)=[N:14][CH:15]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 63651,1-DichloroethaneHCID 86597258(7-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester

Product 1

HCID 86597272HCID 86597272, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester with 4-spiro-[3-(N-methyl-2-pyrrolidone)]-piperidine hydrochloride and pyridine in dichloroethane and tetrahydrofuran. ES-MS m/e (%): 461 (M+H+, 100).

Sources & evidence

ORD record
ord-0cb63a8b6921470f9cf95aceb651a72d
Source dataset
uspto-grants-2007_09
Patent number
US07273865B2

Reaction notes

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