Potassium Carbonate → HCID 22254014, compound

HRID 917500Notes

Reaction equation

HRID 917500 reaction equation
C([NH:9][C:10]([NH:12][CH2:13][CH:14]1[CH2:19][CH2:18][CH:17]([NH:20][C:21](=[O:30])[O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:16][CH2:15]1)=[S:11])(=O)C1C=CC=CC=1.C([O-])([O-])=O.[K+].[K+]>CO.O>[CH2:23]([O:22][C:21](=[O:30])[NH:20][CH:17]1[CH2:16][CH2:15][CH:14]([CH2:13][NH:12][C:10]([NH2:9])=[S:11])[CH2:19][CH2:18]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 22000405HCID 22000405, compound

Product 1

HCID 22254014HCID 22254014, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of benzyl N-[4-({[(benzoyl-amino)carbothioyl]amino}methyl)-cyclohexyl]carbamate (5.023 g, 11.4 mmol) in MeOH (110 ml) was added a solution of K2CO3 (3.5 g, 25.3 mmol) in water (30 ml). The solution was stirred for 24 hours at room temperature and the solvent was removed in vacuo with repeated additions of MeOH to azeotropically remove water. The resulting solid was treated with acetone (60 ml) and filtered. The filtrate was evaporated to yield 95% (3.47 g) of a yellow solid.

Workup

  1. customthe solvent was removed in vacuo with repeated additions of MeOH to azeotropically remove water
  2. additionThe resulting solid was treated with acetone (60 ml)
  3. filtrationfiltered
  4. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-91c005b4747b469289fa15a6ef6baa58
Source dataset
uspto-grants-2007_09
Patent number
US07273880B2

Reaction notes

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