Tetrahydrofuran → HCID 11393616, compound

HRID 917741Notes

Reaction equation

HRID 917741 reaction equation
[NH2:1][O:2][CH2:3][CH2:4][OH:5].[F:6][C:7]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:8]=1[NH:9][C:10]1[C:11]([C:18](O)=[O:19])=[CH:12][N:13]([CH3:17])[C:14](=[O:16])[CH:15]=1.C1COCC1.C[N+]1(C2N=C(OC)N=C(OC)N=2)CCOCC1.[Cl-]>CO>[F:6][C:7]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:8]=1[NH:9][C:10]1[C:11]([C:18]([NH:1][O:2][CH2:3][CH2:4][OH:5])=[O:19])=[CH:12][N:13]([CH3:17])[C:14](=[O:16])[CH:15]=1

Participants

6

Reactant 4

HCID 8028TetrahydrofuranHCID 27340594-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride2×HCID 3014186Ethanol, 2-(aminooxy)-2×HCID 58962854HCID 58962854, compound

Product 1

HCID 11393616HCID 11393616, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2-(Aminooxy)ethanol (0.05 g, 0.6 mmol) in MeOH (1 ml) was added to 4-(2,4-difluoroanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid (0.15 g, 0.5 mmol) in MeOH (20 ml). THF was added dropwise until the reagents dissolved. The solution was stirred at RT for 30 min, after which DMT-MM (0.18 g, 0.6 mmol) was added. After stirring at RT for 60 h, the reaction had not gone to completion. Further 2-(aminooxy)ethanol (0.05 g, 0.6 mmol) and DMT-MM (0.18 g, 0.6 mmol) were added and the reaction mixture stirred for a further 2 h at RT. The solvent was then removed under reduced pressure and the residue dissolved in EtOAc. After washing with water ×2, sat. NaHCO3 and brine, the organic layer was dried (Na2SO4), concentrated and further purified by flash chromatography on silica gel (EtOAc followed by 10% MeOH/CH2Cl2) to give 4-(2,4-difluoroanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide (0.07 g, 39%) as a white solid; m.p. (EtOAc/Hexane) 232-238° C. 1H NMR [400 MHz, (CD3)2SO] δ 11.62 (br s, 1H), 9.21 (br s, 1H), 8.11 (s, 1H), 7.51-7.38 (m, 2H), 7.17-7.11 (m, 1H), 5.30 (s, 1H), 4.76 (br s, 1H), 3.92 (t, J=4.8 Hz, 2H), 3.62 (t, J=4.8 Hz, 2H), 3.34 (s, 3H). LCMS (ACPI+) 340 (100%). Anal. Calcd for C15H15F2N3O4.0.25 H2O: C, 52.4; H, 4.5; N, 12.2. Found C, 52.6; H, 4.5; N, 12.1

Workup

  1. dissolutiondissolved
  2. stirringAfter stirring at RT for 60 h
  3. stirringthe reaction mixture stirred for a further 2 h at RT
  4. customThe solvent was then removed under reduced pressure
  5. dissolutionthe residue dissolved in EtOAc
  6. washAfter washing with water ×2, sat. NaHCO3 and brine
  7. dry with materialthe organic layer was dried (Na2SO4)
  8. concentrationconcentrated
  9. customfurther purified by flash chromatography on silica gel (EtOAc followed by 10% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-1e82cc74755a497a8dfb74c7da229ecc
Source dataset
uspto-grants-2007_09
Patent number
US07273877B2

Reaction notes

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