HRID917799

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)C1CC2CCCCC2N1C(=O)C(NC(=O)C(NC(=O)OCc1ccccc1)C1CCCCC1)C(C)(C)C

HCID68494211

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)C1CC2CCCCC2N1C(=O)C(NC(=O)C(N)C1CCCCC1)C(C)(C)C

HCID68496924

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

CBz ester 15b (3.0 g, 4.9 mmol) was stirred in EtOH (25 mL) and charged with 300 mg 10%Pd(OH)2/C. H2 gas was bubbled into the suspension until the reaction was complete. Catalyst was removed by filtration and the filtrate concentrated in vacuo to give 1-[2-(2-amino-2-cyclohexyl-acetylamino)-3,3-dimethyl-butyryl]-octahydro-indole-2-carboxylic acid tert-butyl ester 16b (2.34 g, 4.9 mmol, 100%) which was used as is in the next step without further purification.

WORKUP

后处理

customH2 gas was bubbled into the suspension until the reaction
customCatalyst was removed by filtration
concentrationthe filtrate concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4f360f164b12416aa67c2e648c20122c
来源数据集: uspto-grants-2007_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07273885B2
来源说明: uspto-grants-2007_09

反应 SMILES

[C:1]([O:5][C:6]([CH:8]1[CH2:16][CH:15]2[CH:10]([CH2:11][CH2:12][CH2:13][CH2:14]2)[N:9]1[C:17](=[O:44])[CH:18]([NH:23][C:24](=[O:43])[CH:25]([NH:32]C(OCC1C=CC=CC=1)=O)[CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[C:19]([CH3:22])([CH3:21])[CH3:20])=[O:7])([CH3:4])([CH3:3])[CH3:2]>CCO.[OH-].[OH-].[Pd+2]>[C:1]([O:5][C:6]([CH:8]1[CH2:16][CH:15]2[CH:10]([CH2:11][CH2:12][CH2:13][CH2:14]2)[N:9]1[C:17](=[O:44])[CH:18]([NH:23][C:24](=[O:43])[CH:25]([NH2:32])[CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1)[C:19]([CH3:22])([CH3:21])[CH3:20])=[O:7])([CH3:2])([CH3:3])[CH3:4]