Hydrofluoric Acid → HCID 20346006, compound

HRID 917807Notes

Reaction equation

HRID 917807 reaction equation
[F:1][C:2]1([F:19])[O:7][C:6]2[CH:8]=[CH:9][C:10](C(C(C)C)=O)=[CH:11][C:5]=2[C:4]([F:18])([F:17])[O:3]1.[Cl:20]C(Cl)(Cl)C1C=C(Cl)C=CC=1OC(F)=O.F>>[F:1][C:2]1([F:19])[O:7][C:6]2[CH:8]=[CH:9][C:10]([Cl:20])=[CH:11][C:5]=2[C:4]([F:18])([F:17])[O:3]1

Participants

4

Reactant 3

HCID 14917Hydrofluoric AcidHCID 20346013HCID 20346013, compoundHCID 53829652HCID 53829652, compound

Product 1

HCID 20346006HCID 20346006, compound

Procedure

For the preparation of a ketone such as isopropyl 2,2,4,4-tetrafluoro-1,3-benzodioxan-6-yl ketone, the procedure disclosed in U.S. Pat. No. 3,632,820 (Jan. 4, 1972), Example 6, is used to prepare the intermediate halobenzodioxane. According to that reference, fluoroformic acid 2-trichloromethyl-4-chlorophenyl ester is allowed to react with anhydrous hydrofluoric acid to yield 2,2,4,4-tetrafluoro-6-chloro-1,3-benzodioxane. This compound can then be utilized to prepare the isopropyl 2,2,4,4-tetrafluoro-1,3-benzodioxan-6-yl or related alkyl or aryl ketones by any of the methods set forth above for the other ketones.

Sources & evidence

ORD record
ord-e8f88050267540368b024a323a59c379
Source dataset
uspto-grants-1976_07
Patent number
US03967949

Reaction notes

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