Diethylaminoethyl chloride → HCID 68129628, compound

HRID 917868Notes

Reaction equation

HRID 917868 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([NH2:19])[CH:13]=2)[C:10]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:9]([CH3:25])[NH:8][C:7]=1[CH3:26])=[O:5])[CH3:2].[CH2:27]([N:29]([CH2:33][CH3:34])[CH2:30][CH2:31]Cl)[CH3:28]>O>[CH2:23]([O:22][C:20]([C:10]1[CH:11]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([NH:19][CH2:28][CH2:27][N:29]([CH2:33][CH3:34])[CH2:30][CH3:31])[CH:13]=2)[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[C:7]([CH3:26])[NH:8][C:9]=1[CH3:25])=[O:21])[CH3:24]

Participants

4

Reactant 2

HCID 13364Diethylaminoethyl chlorideHCID 68129192HCID 68129192, compound

Product 1

HCID 68129628HCID 68129628, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Thirty grams of 2,6-dimethyl-4-(3-amino-6-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (melting point 210°) and 15 ml of 2-diethylaminoethyl chloride are heated for 15 minutes to about 200° and the mixture is taken up in hot water, rendered alkaline after addition of ice and extracted with ether.

Workup

  1. additionafter addition of ice
  2. extractionextracted with ether

Sources & evidence

ORD record
ord-84a6bc845a114e5381dfd17383be66f0
Source dataset
uspto-grants-1976_07
Patent number
US03968117

Reaction notes

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