Azelaic Acid → Bis(2-hydroxyethyl) azelate

反応式

[C:1]([OH:13])(=[O:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].[CH2:14]1[O:16][CH2:15]1.[CH2:17]([C:21](C)=[O:22])C(C)C>>[OH:22][CH2:21][CH2:17][O:10][C:9](=[O:11])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][C:1]([O:13][CH2:15][CH2:14][OH:16])=[O:12]

参加物

反応物 3

HCID 2266Azelaic Acid

HCID 6354Ethylene Oxide

HCID 7909Methyl Isobutyl Ketone

生成物 1

HCID 122426Bis(2-hydroxyethyl) azelate

実験手順

The reaction of 0.25 moles azelaic acid with 0.55 moles ethylene oxide under pressure using methyl isobutyl ketone in the presence of the catalyst of Example II(0.15% by wt. of total system) at 153°C gave bis(2-hydroxy ethyl)azelate in quantitative crude yield. The material was isolated as a grey-white solid melting at 46°-47°C from a n-butyl chloride-acetone mixture in 88.5% yield.

後処理

customat 153°C

出典と根拠

ORDレコード: ord-7af20f6a8218420ca0bb24adaa06b00d
出典データセット: uspto-grants-1976_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03968135

反応ノート

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