Tert-Butylbenzene → 1-(4-tert-Butylphenyl)-2-chloropropan-1-one

HRID 917931노트

반응식

HRID 917931 반응식
[Cl:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[C:7]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:10])([CH3:9])[CH3:8]>>[C:7]([C:11]1[CH:16]=[CH:15][C:14]([C:3](=[O:4])[CH:2]([Cl:1])[CH3:6])=[CH:13][CH:12]=1)([CH3:10])([CH3:9])[CH3:8]

참가 물질

3

반응물 2

HCID 7366Tert-ButylbenzeneHCID 1110192-Chloropropionyl chloride

생성물 1

HCID 38186171-(4-tert-Butylphenyl)-2-chloropropan-1-one

실험 절차

The procedure of Example 3 was followed for the reaction of 63.5g (0.5 mole) of 2-chloropropionyl chloride with 67g (0.5 mole) of tert-butylbenzene. Obtained after high vacuum concentration was 100g of clear, yellow liquid product: ir (film) 3.4 (s), 5.9 (s), 6.3 (s), 8.0 (s), 10.5 (s), 11.8 (s) microns; nmr (CDCl3) 7.67 (4H, d of d), 5.21 (1H, q), 1.67 (3H, d), 1.28 (9H, s) ppm. A VPC analysis indicated one pure product.

후처리

  1. customObtained
  2. concentrationafter high vacuum concentration

출처 및 근거

ORD 기록
ord-db2e1a64123c4073a4d8e2d7f4a02d06
출처 데이터셋
uspto-grants-1976_07
특허 번호
US03968168

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