3-(2-Pyridinyl)Propanenitrile → 3-(Pyridin-2-yl)propan-1-amine

HRID 917952Notes

Reaction equation

HRID 917952 reaction equation
[C:1]([CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)#[N:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[NH2:2][CH2:1][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 146872203-(2-Pyridinyl)PropanenitrileHCID 21226445Aluminium lithium hydride

Product 1

HCID 31596143-(Pyridin-2-yl)propan-1-amine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(2-Cyanoethyl)pyridine is reduced with lithium aluminum hydride in ether, in the normal way, yielding 2-(3-aminopropyl) pyridine, b.p. 77°C/0.4 mm. (Dihydrochloride, m.p. 175°-177°C).

Sources & evidence

ORD record
ord-67b11073242a42b68ffbc6e097715d25
Source dataset
uspto-grants-1976_07
Patent number
US03968216

Reaction notes

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