Dimethylformamide → HCID 178433679, compound

HRID 918022Notes

Reaction equation

HRID 918022 reaction equation
[N:1]#[C:2][NH2:3].[Pb].[CH3:5][C:6]1[NH:10][CH:9]=[N:8][C:7]=1[CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16](=S)[NH:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])=S.C[N:37]([CH3:40])C=O.C(#[N:43])C>>[C:2]([N:3]=[C:22]([NH:24][CH2:25][CH2:26][S:27][CH2:28][C:29]1[N:30]=[CH:31][NH:32][C:33]=1[CH3:34])[NH:21][CH2:20][CH2:19][CH2:18][NH:17][C:16]([NH:15][CH2:14][CH2:13][S:12][CH2:11][C:7]1[N:8]=[CH:9][NH:10][C:6]=1[CH3:5])=[N:43][C:40]#[N:37])#[N:1]

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6342AcetonitrileHCID 22262466CH2N2PbHCID 537592711,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane

Product 1

HCID 178433679HCID 178433679, compound

Procedure

Lead cyanamide (3.0 g) was added to 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)thioureido] propane (2.5 g) in acetonitrile. Dimethylformamide was added and the mixture was stirred and boiled under reflux for 24 hours. The mixture was filtered, concentrated and purified by chromatography to give the title compound.

Workup

  1. temperatureunder reflux for 24 hours
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-ded8d62550614758bae9f45c7ffb6350
Source dataset
uspto-grants-1976_07
Patent number
US03968227

Reaction notes

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