反应详情

A mixture consisting of 6.11 gm (0.025 mol) of 3-(2-fluoro-4-biphenylyl)-1-butanol, 4.27 gm (0.027 mol) of pelargonic acid, 0.25 gm of p-toluene-sulfonic acid and 50 ml of absolute toluene was refluxed in a vessel equipped with a water trap until no more water separated out. Thereafter, the reaction solution was diluted with ether, the organic solution was extracted with water, dilute ammonia and again with water, dried over sodium sulfate, and the solvent was distilled off. 6.45 gm (67% of theory) of the ester of the formula ##EQU26## having a boiling point of 183°-190°C at 0.1 mm Hg were obtained.

1. temperaturewas refluxed in a vessel
2. customseparated out
3. additionThereafter, the reaction solution was diluted with ether
4. extractionthe organic solution was extracted with water, dilute ammonia and again with water
5. dry with materialdried over sodium sulfate
6. distillationthe solvent was distilled off
7. customwere obtained