HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → 5-Fluoro-2-methylindan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Reactant | 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one | HCID 21521891 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
Reaction Steps
A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for 1 hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03970693 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-56b74baa0a614ec9aaab0a21a089124b |
| Source note | uspto-grants-1976_07 |