O-Xylene → 5-Fluoro-2-methylindan-1-one

HRID 918284Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 918284
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.C1(C)C(C)=CC=CC=1>O>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]2

Komponenten

5

Edukt 3

HCID 7237O-XyleneHCID 14812Phosphorus oxide (P4O10)HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

Produkt 1

HCID 30162575-Fluoro-2-methylindan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for 1 hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Aufarbeitung

  1. additionA mixture of 18.2 g
  2. temperatureThe reaction is cooled
  3. washthe xylene layer is washed with aqueous sodium hydroxide and water
  4. concentrationThe organic layer is then concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-56b74baa0a614ec9aaab0a21a089124b
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03970693

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