反应详情

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for 1 hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

1. additionA mixture of 18.2 g
2. temperatureThe reaction is cooled
3. washthe xylene layer is washed with aqueous sodium hydroxide and water
4. concentrationThe organic layer is then concentrated in vacuo