Fluorobenzene → 1-(4-Fluorophenyl)-2-methylprop-2-en-1-one

HRID 918287Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 918287
[Cl-].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[C:12](Cl)(=[O:16])[C:13]([CH3:15])=[CH2:14]>>[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:16])[C:13]([CH3:15])=[CH2:14])=[CH:8][CH:7]=1

Komponenten

4

Edukt 3

HCID 10008FluorobenzeneHCID 13528Methacryloyl chlorideHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 132782011-(4-Fluorophenyl)-2-methylprop-2-en-1-one

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

A slurry of 29.4 g. (0.220 mole) of anhydrous aluminum chloride in 38.4 g. (0.40 mole) of fluorobenzene under nitrogen is cooled to 15°C. Methacrylyl chloride (21.9 g., 0.200 mole) is then added dropwise over 30 minutes while holding the temperature at 15° to 20°C. The mixture is warmed to 30°C over 10 minutes, stirred at 30°C for 10 minutes and quenched in ice. The product is extracted into hexane. The hexane layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 4'-fluoro-2-methylacrylophenone.

Aufarbeitung

  1. customat 15° to 20°C
  2. customquenched in ice
  3. extractionThe product is extracted into hexane
  4. dry with materialThe hexane layer is dried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b69716cdfe5244289d810e2fd23237b7
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03970693

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