Sulfuric Acid → 5-Fluoro-2-methylindan-1-one

HRID 918292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 918292
CN(C)[CH2:3][CH:4]([CH3:14])[C:5]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)=[O:6].S(=O)(=O)(O)O>>[F:13][C:10]1[CH:9]=[C:8]2[C:7](=[CH:12][CH:11]=1)[C:5](=[O:6])[CH:4]([CH3:14])[CH2:3]2

Komponenten

3

Edukt 2

HCID 1118Sulfuric AcidHCID 215218873-(Dimethylamino)-1-(4-fluorophenyl)-2-methylpropan-1-one

Produkt 1

HCID 30162575-Fluoro-2-methylindan-1-one

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over 1 hour and stirred at 90°C for 2 hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Aufarbeitung

  1. additionA mixture of 42 g
  2. temperatureThe reaction is cooled
  3. customquenched in ice
  4. extractionthe product extracted into toluene
  5. washThe toluene layer is washed with aqueous sodium hydroxide and water
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fffcee4c24c84bcb967d013ebb958a6e
Quelldatensatz
uspto-grants-1976_07
Patentnummer
US03970693

Notizen zur Reaktion

Wird geladen…