HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918292Generated: October 26, 2026
Sulfuric Acid → 5-Fluoro-2-methylindan-1-one
https://huagongshe.com/reaction/918292
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 3-(Dimethylamino)-1-(4-fluorophenyl)-2-methylpropan-1-one | HCID 21521887 | — |
| Product | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
Reaction Steps
A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over 1 hour and stirred at 90°C for 2 hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03970693 |
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| Source dataset | uspto-grants-1976_07 |
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| ORD ID | ord-fffcee4c24c84bcb967d013ebb958a6e |
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| Source note | uspto-grants-1976_07 |
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