反应详情

500 mg. (1.755 mm) of 5-fluoro-2-methyl-1-(p-methylthiobenzyl)-indene is dissolved in 5 ml. of chloroform. To this solution is added 30% hydrogen peroxide (equivalent to 2.645 mm). The reaction mixture is aged for 1 hour at room temperature followed by the addition of 5 ml. of glacial acetic acid and aged for an additional hour. The reaction mixture is then diluted with 25 ml. of 1:1 benzene-ether and extracted with 6 × 25 ml. of 3% aqueous sodium chloride. The solution is then dried over sodium sulfate and evaporated in vacuo to yield an oil. Recrystallization from ice-cold isopropanol gives 5-fluoro-2-methyl-1-(p-methylsulfinylbenzyl)-indene.

1. additionfollowed by the addition of 5 ml
2. additionThe reaction mixture is then diluted with 25 ml
3. extractionof 1:1 benzene-ether and extracted with 6 × 25 ml
4. dry with materialThe solution is then dried over sodium sulfate
5. customevaporated in vacuo
6. customto yield an oil
7. customRecrystallization from ice-cold isopropanol