HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Chloro-3-cyclohexyl-1-methyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Cyclohexyl-2-methyl-2,4-dihydro-3H-pyrazol-3-one | HCID 15203938 | — |
| Product | 5-Chloro-3-cyclohexyl-1-methyl-1H-pyrazole | HCID 15203939 | — |
Reaction Steps
Phosphorus oxychloride (15.3 g, 0.1 mole) is added to 3-cyclohexyl-1-methyl-2-pyrazolin-5-one and the mixture stirred and heated at 120°C. to 135°C. for 8 hours. The cooled reaction mixture is then poured into ice-water, made alkaline with 1% aqueous sodium hydroxide and extracted with methylene chloride. Removal of solvent under reduced pressure, then in vacuo at 70°C. affords an oil, 8 g, (93.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03970754 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-e328f5a0bbf64ef580952f7cde339859 |
| Source note | uspto-grants-1976_07 |