反应详情

Phosphorus oxychloride (15.3 g, 0.1 mole) is added to 3-cyclohexyl-1-methyl-2-pyrazolin-5-one and the mixture stirred and heated at 120°C. to 135°C. for 8 hours. The cooled reaction mixture is then poured into ice-water, made alkaline with 1% aqueous sodium hydroxide and extracted with methylene chloride. Removal of solvent under reduced pressure, then in vacuo at 70°C. affords an oil, 8 g, (93.8%).

1. temperatureheated at 120°C. to 135°C. for 8 hours
2. customThe cooled reaction mixture
3. extractionextracted with methylene chloride
4. customRemoval of solvent under reduced pressure
5. customin vacuo at 70°C. affords an oil, 8 g, (93.8%)