HRID918387

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54028073

2-(1-Diazoethyl)-2-phenyl-1,3-dioxolane

C11H12N2O2

结构：C[C@]12C=CC(=O)C=C1CC[C@H]1[C@@H]3C[C@@H](O)[C@](O)(C(=O)CCl)[C@@]3(C)C[C@H](O)[C@@]12F

HCID86733740

未命名化合物

PRODUCTS

生成物

结构：CC(O[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl)C(=O)c1ccccc1

HCID86733751

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

CONDITIONS

反应条件

温度: 0 °C

PROCEDURE

实验过程

A solution of 2-phenyl-2-(1-diazoethyl)dioxolane in 3:2 ether-pentane is diluted with methanol and cooled to 0°C. 21-Chloro-9-fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate is added in portions until nitrogen evolution ceases. The solvent is removed in vacuo.

WORKUP

后处理

customThe solvent is removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fe32e0c37f804cbfa7576eb9cca542e4
来源数据集: uspto-grants-1976_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03971772
来源说明: uspto-grants-1976_07

反应 SMILES

[C:1]1([C:7]2([C:12](=[N+]=[N-])[CH3:13])[O:11]CCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:16][CH2:17][C:18](=[O:43])[C@:19]1([OH:42])[C@:36]2([CH3:37])[C@H:22]([C@H:23]3[C@:33]([F:39])([C@@H:34]([OH:38])[CH2:35]2)[C@:31]2([CH3:32])[C:26](=[CH:27][C:28](=[O:40])[CH:29]=[CH:30]2)[CH2:25][CH2:24]3)[CH2:21][C@H:20]1[OH:41]>CO>[Cl:16][CH2:17][C:18](=[O:43])[C@:19]1([OH:42])[C@:36]2([CH3:37])[C@H:22]([C@H:23]3[C@:33]([F:39])([C@@H:34]([OH:38])[CH2:35]2)[C@:31]2([CH3:32])[C:26](=[CH:27][C:28](=[O:40])[CH:29]=[CH:30]2)[CH2:25][CH2:24]3)[CH2:21][C@H:20]1[O:41][CH:12]([C:7](=[O:11])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH3:13]