HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918387Generated: October 31, 2026
2-(1-Diazoethyl)-2-phenyl-1,3-dioxolane → 21-Chloro-9-fluoro-11beta,17-dihydroxy-16alpha-[(3-oxo-3-phenylprop-2-yl)oxy]pregna-1,4-diene-3,20-dione
https://huagongshe.com/reaction/918387
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(1-Diazoethyl)-2-phenyl-1,3-dioxolane | HCID 54028073 | — |
| Reactant | 21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregna-1,4-diene-3,20-dione | HCID 86733740 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 21-Chloro-9-fluoro-11beta,17-dihydroxy-16alpha-[(3-oxo-3-phenylprop-2-yl)oxy]pregna-1,4-diene-3,20-dione | HCID 86733751 | — |
Reaction Steps
A solution of 2-phenyl-2-(1-diazoethyl)dioxolane in 3:2 ether-pentane is diluted with methanol and cooled to 0°C. 21-Chloro-9-fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate is added in portions until nitrogen evolution ceases. The solvent is removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03971772 |
|---|
| Source dataset | uspto-grants-1976_07 |
|---|
| ORD ID | ord-fe32e0c37f804cbfa7576eb9cca542e4 |
|---|
| Source note | uspto-grants-1976_07 |
|---|
