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HRID918403

反应详情

EQUATION

反应方程式

HRID 918403 的结构方程式

REACTANTS

反应物

3
结构：C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1C[C@@H](O)[C@]2(O)C(=O)CO
HCID102003

11,16,17,21-Tetrahydroxypregn-4-ene-3,20-dione

C21H30O6

结构：CCOC(CNC(N)=O)OCC
HCID1713901

Urea, (2,2-diethoxyethyl)-

C7H16N2O3

结构：CCOC(C=[N+]=[N-])OCC
HCID21520892

Ethane, 2-diazo-1,1-diethoxy-

C6H12N2O2

PRODUCTS

生成物

1
结构：CCOC(CO[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO)OCC
HCID68143162

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CCCCC.CCOCC
溶剂HCID21877078

未命名化合物

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

A solution of 2,2-diethoxy-1-diazoethane (prepared from 0.0935 mole of N-2,2-diethoxyethyl urea by the method of W. Kirmse and B. Buschhoff, Chem. Ber., 100, 1491 (1967)) in 300 ml of 3:2 ether pentane is diluted with 100 ml of methanol and cooled to 0°C. 11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione, 16,17-cycloborate is added in portions until nitrogen evolution ceases. The solvent is removed in vacuo and the residue is recrystallized from methanol to yield the title compound.

WORKUP

后处理

  1. customThe solvent is removed in vacuo
  2. customthe residue is recrystallized from methanol