HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 918403Generated: October 30, 2026
11beta,16alpha,17,21-Tetrahydroxypregn-4-ene-3,20-dione → 16alpha-(2,2-Diethoxyethoxy)-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
https://huagongshe.com/reaction/918403
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 11beta,16alpha,17,21-Tetrahydroxypregn-4-ene-3,20-dione | HCID 102003 | — |
| Reactant | Urea, (2,2-diethoxyethyl)- | HCID 1713901 | — |
| Reactant | Ethane, 2-diazo-1,1-diethoxy- | HCID 21520892 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Diethylether pentane | HCID 21877078 | — |
| Product | 16alpha-(2,2-Diethoxyethoxy)-11beta,17,21-trihydroxypregn-4-ene-3,20-dione | HCID 68143162 | — |
Reaction Steps
A solution of 2,2-diethoxy-1-diazoethane (prepared from 0.0935 mole of N-2,2-diethoxyethyl urea by the method of W. Kirmse and B. Buschhoff, Chem. Ber., 100, 1491 (1967)) in 300 ml of 3:2 ether pentane is diluted with 100 ml of methanol and cooled to 0°C. 11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione, 16,17-cycloborate is added in portions until nitrogen evolution ceases. The solvent is removed in vacuo and the residue is recrystallized from methanol to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03971773 |
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| Source dataset | uspto-grants-1976_07 |
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| ORD ID | ord-7503150db3f24ed69c50a2ca3de1ccfc |
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| Source note | uspto-grants-1976_07 |
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