HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethane, 2-diazo-1,1-diethoxy- → 6alpha-Fluoro-16alpha-[(2,2-diethoxy)ethoxy]-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethane, 2-diazo-1,1-diethoxy- | HCID 21520892 | — |
| Reactant | 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione | HCID 22793229 | — |
| Product | 6alpha-Fluoro-16alpha-[(2,2-diethoxy)ethoxy]-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione | HCID 22791783 | — |
Reaction Steps
A solution of 2,2-diethoxy-1-diazoethane (prepared from 0.18 mole of precursor as described in Example 2A) in methanolether at 0°C is treated with 6α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, 16,17-cycloborate until nitrogen evolution ceases. The solution is evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971773 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-ce729fb729ad438ca1ac2e3c7d45e9a4 |
| Source note | uspto-grants-1976_07 |