m-Chloroperbenzoic acid → HCID 86733754, compound

HRID 918408Notes

Reaction equation

HRID 918408 reaction equation
[Cl:1][CH2:2][C:3](=[O:31])[C@:4]1([OH:30])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][C:27]([CH3:29])=[CH2:28].ClC1C=CC=C(C(OO)=[O:40])C=1>ClCCl>[Cl:1][CH2:2][C:3](=[O:31])[C@:4]1([OH:30])[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C@@H:19]([OH:23])[CH2:20]2)[C@:16]2([CH3:17])[C:11](=[CH:12][C:13](=[O:24])[CH:14]=[CH:15]2)[CH2:10][CH2:9]3)[CH2:6][C@H:5]1[O:25][CH2:26][C:27]1([CH3:29])[CH2:28][O:40]1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 22791781HCID 22791781, compound

Product 1

HCID 86733754HCID 86733754, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 21-chloro-11β,17-dihydroxy-16α-(2-methyl-2-propenyloxy)pregna-1.4-diene-3,20-dione (16 mmoles) in 300 ml of dichloromethane is stirred with 3.2 g of m-chloroperbenzoic acid for 3 hours. The solution is washed with a mixture of 5% sodium bicarbonate solution and 5% sodium sulfite solution, dried, and evaporated to give the title compound.

Workup

  1. washThe solution is washed with a mixture of 5% sodium bicarbonate solution and 5% sodium sulfite solution
  2. customdried
  3. customevaporated

Sources & evidence

ORD record
ord-c47b35ec3bf94cada34fbd7c67048e59
Source dataset
uspto-grants-1976_07
Patent number
US03971773

Reaction notes

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