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HRID918422

反应详情

EQUATION

反应方程式

HRID 918422 的结构方程式

REACTANTS

反应物

2
结构：Cc1cccc(CSCCN)n1
HCID20362805

未命名化合物

结构：CN=C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)SC
HCID22756464

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=NCCSCc1cccc(C)n1)NS(=O)(=O)c1ccc(Cl)c(Cl)c1
HCID178484978

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of 6-methyl-2-((2-aminoethyl)thiomethyl) pyridine (3.7 g) and N-(3,4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea (6.2 g) in acetonitrile (250 ml) was heated under reflux for 48 hours. Concentration, followed by chromatographic purification on a column of alumina afforded N-(3,4-dichlorobenzenesulphonyl)-N'-methyl-N"-[2-((6-methyl-2-pyridyl)methylthio)ethyl]guanidine.

WORKUP

后处理

  1. temperatureunder reflux for 48 hours
  2. concentrationConcentration
  3. customfollowed by chromatographic purification on a column of alumina