HCID 20362805, compound → HCID 178484978, compound

HRID 918422Notes

Reaction equation

HRID 918422 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8][S:9][CH2:10][CH2:11][NH2:12])[CH:5]=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:15]=[C:16]([S:21]([NH:24][C:25](=[N:28][CH3:29])SC)(=[O:23])=[O:22])[CH:17]=[CH:18][C:19]=1[Cl:20]>C(#N)C>[Cl:13][C:14]1[CH:15]=[C:16]([S:21]([NH:24][C:25]([NH:28][CH3:29])=[N:12][CH2:11][CH2:10][S:9][CH2:8][C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=2)(=[O:22])=[O:23])[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

4

Reactant 2

HCID 20362805HCID 20362805, compoundHCID 22756464N-(3,4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea

Product 1

HCID 178484978HCID 178484978, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 6-methyl-2-((2-aminoethyl)thiomethyl) pyridine (3.7 g) and N-(3,4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea (6.2 g) in acetonitrile (250 ml) was heated under reflux for 48 hours. Concentration, followed by chromatographic purification on a column of alumina afforded N-(3,4-dichlorobenzenesulphonyl)-N'-methyl-N"-[2-((6-methyl-2-pyridyl)methylthio)ethyl]guanidine.

Workup

  1. temperatureunder reflux for 48 hours
  2. concentrationConcentration
  3. customfollowed by chromatographic purification on a column of alumina

Sources & evidence

ORD record
ord-b5820b28d52b412fbe641d0674413f0c
Source dataset
uspto-grants-1976_07
Patent number
US03971786

Reaction notes

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