HCID 12951531, compound → HCID 178426300, compound

HRID 918423Notes

Reaction equation

HRID 918423 reaction equation
[CH3:1][C:2]1[C:3]([CH2:8][S:9][CH2:10][CH2:11][NH2:12])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:13]1([S:19]([NH:22][C:23](=[NH:26])SC)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(#N)C>[C:13]1([S:19]([NH:22][C:23]([NH:12][CH2:11][CH2:10][S:9][CH2:8][C:3]2[C:2]([CH3:1])=[CH:7][CH:6]=[CH:5][N:4]=2)=[NH:26])(=[O:20])=[O:21])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 12951531HCID 12951531, compoundHCID 178504065HCID 178504065, compound

Product 1

HCID 178426300HCID 178426300, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 3-methyl-2-((2-aminoethyl)thiomethyl)pyridine (6.3 g) and N-benzenesulphonyl-S-methylisothiourea (8.0 g) in acetonitrile (100 ml) was heated under reflux for 24 hours. Concentration, followed by chromatographic purification on a column of silica gel and recrystallisation afforded N-benzenesulphonyl-N'-[2-((3-methyl-2-pyridyl)methylthio)ethyl] guanidine.

Workup

  1. temperatureunder reflux for 24 hours
  2. concentrationConcentration
  3. customfollowed by chromatographic purification on a column of silica gel and recrystallisation

Sources & evidence

ORD record
ord-d4ad78684e0445248c303b468e475b5a
Source dataset
uspto-grants-1976_07
Patent number
US03971786

Reaction notes

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