Anthranilic Acid → 2-((7-(Trifluoromethyl)-4-quinolinyl)amino)benzoic acid

HRID 918434Notes

Reaction equation

HRID 918434 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=1[C:19]([OH:21])=[O:20]>Cl>[F:13][C:12]([F:15])([F:14])[C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:16][C:17]3[CH:25]=[CH:24][CH:23]=[CH:22][C:18]=3[C:19]([OH:21])=[O:20])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 227Anthranilic AcidHCID 676684-Chloro-7-(trifluoromethyl)quinoline

Product 1

HCID 1698112-((7-(Trifluoromethyl)-4-quinolinyl)amino)benzoic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

4-Chloro-7-trifluoromethylquinoline and 2-amino benzoic acid are refluxed in dilute hydrochloric acid for 1 hour to give 2-(7-trifluoromethyl-4-quinolylamino)benzoic acid.

Sources & evidence

ORD record
ord-43e2b0a8ebe1422e9858ad3d5e5a92df
Source dataset
uspto-grants-1976_07
Patent number
US03971789

Reaction notes

Loading…