2-Bromopropane → 5-Isopropylthiopyrano[3,2-b]indol-4(5H)-one

HRID 918480Notes

Reaction equation

HRID 918480 reaction equation
[S:1]1[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[NH:6][C:5]=2[C:4](=[O:14])[CH:3]=[CH:2]1.[CH:15](Br)([CH3:17])[CH3:16]>>[CH:15]([N:6]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=2[C:13]2[S:1][CH:2]=[CH:3][C:4](=[O:14])[C:5]1=2)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 20326608Thiopyrano[3,2-b]indol-4(5H)-one

Product 1

HCID 203266165-Isopropylthiopyrano[3,2-b]indol-4(5H)-one

Procedure

By the same method as described in Example 7, 4.8 g of thiopyrano-[3,2-b]indol-4(5H)-one is alkylated with isopropyl bromide to give 2.4 of product, mp 154-6°C, after recrystallization from methylene chloride-hexane.

Workup

  1. customto give 2.4 of product, mp 154-6°C
  2. customafter recrystallization from methylene chloride-hexane

Sources & evidence

ORD record
ord-dd6823d45c534ad58453908ebb3f2116
Source dataset
uspto-grants-1976_07
Patent number
US03971806

Reaction notes

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