HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → Diethyl 2-amino-4-(2-furyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Ethyl 2-(furan-2-ylmethylidene)-3-oxobutanoate | HCID 252577 | — |
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl 2-amino-4-(2-furyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate | HCID 4601376 | 78% |
Reaction Steps
Upon boiling a solution of 10.4 g of 2-furfurylideneacetoacetic acid ethyl ester and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 2 hours, 2-amino-6-methyl-4-(fur-2-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 183°C (isopropanol) is obtained. Yield: 78% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03971791 |
| Source dataset | uspto-grants-1976_07 |
| ORD ID | ord-e03c68f4b79c41f6aad907eff35c7eb3 |
| Source note | uspto-grants-1976_07 |