Ethanol → HCID 12391093, compound

HRID 918508Notes

Reaction equation

HRID 918508 reaction equation
C(OC(=O)C[C:7]([CH:9]=[CH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=1)=[O:8])(C)C.[CH2:21]([O:24][C:25](=[O:30])[CH2:26][C:27](=[NH:29])[NH2:28])[CH2:22][CH3:23].[CH:31]([OH:34])([CH3:33])[CH3:32].[CH2:35](O)[CH3:36]>>[CH:31]([O:34][C:7]([C:9]1[CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=2)[C:26]([C:25]([O:24][CH2:21][CH2:22][CH3:23])=[O:30])=[C:27]([NH2:28])[NH:29][C:35]=1[CH3:36])=[O:8])([CH3:33])[CH3:32]

Participants

5

Reactant 4

HCID 702EthanolHCID 3776IsopropanolHCID 12391078HCID 12391078, compoundHCID 54329362HCID 54329362, compound

Product 1

HCID 12391093HCID 12391093, compoundYield 75%

Procedure

Upon heating a solution of 13.9 g of 3-nitrobenzylideneacetoacetic acid isopropyl ester and 7.2 g of amidinoacetic acid n-propyl ester in 100 ml of ethanol for 6 hours, 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-n-propyl ester 5-isopropyl ester of melting point 199°C (isopropanol) is obtained. Yield: 75% of theory.

Sources & evidence

ORD record
ord-4bb7e6816de8427aadcec7d90827975e
Source dataset
uspto-grants-1976_07
Patent number
US03971791

Reaction notes

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