Ethylamine → HCID 178464563, compound

HRID 918548Notes

Reaction equation

HRID 918548 reaction equation
[OH:1][C:2]1[C:3]2[CH:15]=[CH:14][CH:13]=[CH:12][C:4]=2[S:5][C:6]=1[C:7](=[NH:11])OCC.[CH2:16]([NH2:18])[CH3:17]>>[CH2:16]([NH:18][C:7]([C:6]1[S:5][C:4]2[CH:12]=[CH:13][CH:14]=[CH:15][C:3]=2[C:2]=1[OH:1])=[NH:11])[CH3:17]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 3040799Ethyl 3-hydroxybenzo(b)thiophene-2-carboximidate

Product 1

HCID 178464563HCID 178464563, compoundYield 67%

Procedure

3 g of ethyl 3-hydroxy-benzo[b]thiophene-2-carboximidate (Example 2) are heated under reflux for 10 hours in 20 g of 33% aqueous ethylamine solution. The residue obtained after evaporation is recrystallized from an ethyl acetate/isopropanol solution and yields 2 g of the product.

Workup

  1. customThe residue obtained
  2. customafter evaporation
  3. customis recrystallized from an ethyl acetate/isopropanol solution

Sources & evidence

ORD record
ord-7d6f3dc348fd4f9994226bf8ca7a731a
Source dataset
uspto-grants-1976_07
Patent number
US03971814

Reaction notes

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