Isopropanol → HCID 178473626, compound

HRID 918573Notes

Reaction equation

HRID 918573 reaction equation
[ClH:1].[Cl:2]C[C:4]1[C:5]([CH2:17][O:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:6]([O:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:7]([CH3:10])=[N:8][CH:9]=1.[NH2:24][C:25]([NH2:27])=[S:26].[CH:28](O)(C)C>>[ClH:2].[ClH:1].[CH2:15]([O:14][C:12]([O:11][C:6]1([CH2:28][NH:24][C:25](=[NH:27])[SH:26])[C:5]([CH2:17][O:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:4][CH:9]=[N:8][CH:7]1[CH3:10])=[O:13])[CH3:16]

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 2723790ThioureaHCID 20330524HCID 20330524, compound

Product 1

HCID 178473626HCID 178473626, compound

Procedure

A mixture of 0.1 mole of 5-chloromethyl-3-ethoxycarbonyloxy-4-ethoxycarbonyloxymethyl-2-methylpyridine hydrochloride, 0.11 mole of thiourea are refluxed 2 hours in 100 ml. isopropanol. The reaction mixture is cooled and 3-ethoxycarbonyloxy-4-ethoxycarbonyloxymethyl-3-isothioureidomethyl-2-methylpyridine dihydrochloride is separated by filtration.

Workup

  1. temperatureare refluxed 2 hours in 100 ml
  2. temperatureThe reaction mixture is cooled
  3. custom3-ethoxycarbonyloxy-4-ethoxycarbonyloxymethyl-3-isothioureidomethyl-2-methylpyridine dihydrochloride is separated by filtration

Sources & evidence

ORD record
ord-4060dac0ca2242b5bab9f968a366585d
Source dataset
uspto-grants-1976_07
Patent number
US03971797

Reaction notes

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