反应详情

To a solution of 4-chloro-3-nitro-5-chlorosulphonyl-benzoic acid (6 g) in ethyl acetate (50 ml), aniline (7.5 g) was added, while stirring. The reaction mixture was stirred for a further 8 hours and filtered. The filtrate was evaporated, and the residue was dissolved in a mixture of aqueous sodium hydrogen carbonate and diethyl ether. The aqueous layer was separated, and the 4-anilino-3-nitro-5-phenylsulphamyl-benzoic acid was precipitated by addition of 4N hydrochloric acid. After recrystallization from aqueous ethanol (25% ethanol in water), the melting point was 249°-250°C.

1. stirringThe reaction mixture was stirred for a further 8 hours
2. filtrationfiltered
3. customThe filtrate was evaporated
4. dissolutionthe residue was dissolved in a mixture of aqueous sodium hydrogen carbonate and diethyl ether
5. customThe aqueous layer was separated
6. customthe 4-anilino-3-nitro-5-phenylsulphamyl-benzoic acid was precipitated by addition of 4N hydrochloric acid
7. customAfter recrystallization from aqueous ethanol (25% ethanol in water)