反应详情

A mixture of 4-chloro-3-nitro-5-sulphamyl-benzoic acid (22.4 g), β-phenylethylamine (29 g), and water (200 ml) was refluxed for 2.5 hours. After cooling, the reaction mixture was adjusted to a pH of 9.5 and extracted with diethyl ether. The aqueous layer was then acidified by addition of 4N hydrochloric acid, and the precipitated 3-nitro-4-(β-phenylethylamino)-5-sulphamyl-benzoic acid was collected by suction. After recrystallization from aqueous ethanol, the melting point was 208°-208.5°C.

1. temperaturewas refluxed for 2.5 hours
2. temperatureAfter cooling
3. extractionextracted with diethyl ether
4. additionThe aqueous layer was then acidified by addition of 4N hydrochloric acid
5. customthe precipitated 3-nitro-4-(β-phenylethylamino)-5-sulphamyl-benzoic acid was collected by suction
6. customAfter recrystallization from aqueous ethanol