Hydrochloric Acid → HCID 21506018, compound

HRID 918676Notes

Reaction equation

HRID 918676 reaction equation
[CH2:1]([NH:6][C:7]1[CH:8]=[C:9]([CH:18]=[C:19]([S:28](=[O:31])(=[O:30])[NH2:29])[C:20]=1[O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:10]([O:12]CCCCC)=[O:11])[CH2:2][CH2:3][CH2:4][CH3:5].Cl>[OH-].[Na+]>[CH2:1]([NH:6][C:7]1[CH:8]=[C:9]([CH:18]=[C:19]([S:28](=[O:31])(=[O:30])[NH2:29])[C:20]=1[O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:10]([OH:12])=[O:11])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21505996HCID 21505996, compound

Product 1

HCID 21506018HCID 21506018, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A mixture of n-pentyl 3-n-pentylamino-4-phenoxy-5-sulphamyl-benzoate (4.5 g) and 1N sodium hydroxide (70 ml) was heated on a steam bath for 1 hour. After cooling, the reaction mixture was adjusted to a pH of 2.5 by addition of 4N hydrochloric acid. The precipitated 3-n-pentylamino-4-phenoxy-5-sulphamyl-benzoic acid was isolated by filtration and recrystallized from aqueous ethanol. After drying in vacuo, the compound was obtained with a melting point of 223°-224°C.

Workup

  1. temperaturewas heated on a steam bath for 1 hour
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-5df0d8ddcf074c00a3542e3875e2dd8d
Source dataset
uspto-grants-1976_07
Patent number
US03971819

Reaction notes

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