反应详情

A mixture of 3-amino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoic acid (1.82 g), benzyl bromide (2 g), and anhydrous ethanol (15 ml) was refluxed for 7 hours. The soluton was cooled, and the precipitated ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoate was collected by suction. After recrystallization from ethanol, the melting pont was 166°-168°C.

1. temperaturewas refluxed for 7 hours
2. temperatureThe soluton was cooled
3. customthe precipitated ethyl 3-benzylamino-5-sulphamyl-4-(m-trifluoromethylphenoxy)-benzoate was collected by suction
4. customAfter recrystallization from ethanol
5. customwas 166°-168°C.