反应详情

A mixture of 3-amino-5-sulphamyl-4-(β, β, β-trifluoroethoxy)-benzoic acid (0.6 g), benzyl bromide (1.2 g), and dry ethanol (8 ml) was refluxed for 5 hours. After cooling, the precipitated ethyl 3-benzylamino-5-sulphamyl-4-(β, β, β-trifluoroethoxy)-benzoate was collected by suction and recrystallized from dry ethanol. After drying, the compound had a melting point of 163-165°C.

1. temperaturewas refluxed for 5 hours
2. temperatureAfter cooling
3. customthe precipitated ethyl 3-benzylamino-5-sulphamyl-4-(β, β, β-trifluoroethoxy)-benzoate was collected by suction
4. customrecrystallized from dry ethanol
5. customAfter drying